At the start of the game, disable your weapons and never turn them back on.
Never install anything to your ship. (I figured this was the logical extension of "never using weapons" - never installing shields and armor forced me to make strategic use of Sustain).
I also ended up never using any items (barrels, autons, ROMs etc) other than the Gem of Sacrifice. Not sure it's winnable without the Gem since I'm pretty sure a Shatter+Circle of Wrath won't kill the ICS in one go.
Strategy: Scrounge for wrecks and random containers you find. Goals here are money and anything illegal (to get a Black Market ID). Once you do, buy slave coffins (I think 20 is enough) and give them to Sisters. Once you get Shatter, do the Antarctica mission for the Gem, then go to Heretic.
Heretic's kinda hard - Shatter and Circle of Wrath are your only damage-dealers and they don't kill the pteravore lairs, so I lost the Svalbard Explorer and had to get 3 ROMs instead of just 1. I got 1 from the neurohack mission, and I don't think any of the others are doable: MRAD needs you to install a device, I don't think Shatter can kill the Iocrym outpost or the Ark, and I killed the Huygens Explorer with Shatter which obviously didn't get me the ROM. Might have been able to do that with CoW but idk.
So I had to cheese the sentinel waves to get the other two ROMs. There are two strategies I know of here: hide out on an asteroid near the Commonwealth station by the gate - the guards will wail on the sentinels but they won't fight back since they're focused on you (Bug? They really should attack the settlement since they're killing everything else). OR you can kite the sentinels around the middle of the system and let the pteravores eat them. I got one ROM using each method.
Once I had the 3 ROMS it's just Sustain (actually I used Defend on a whim) - Gem - Shatter (You can't shatter the ICS) and you're done. In a way it was actually a bit easier than a normal game.
Might try another conduct sometime. I know the game tracks "No backtracking" so that sounds interesting.
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BLASTENDEDSQRT Adventure Domina & Oracus I: The Stars of the Pilgrim Black Market rank Smuggler Domina relationship Canon Fate Left Human Space on a journey to the Galactic Core Game Registered Genome Human male Money (credits) 21 Score 39,948 Ship class Wolfen-class gunship Time played 3 hours and 59 minutes Version 1.7 ACHIEVEMENTS & REGRETS Defended the CSC Antarctica COMBAT Enemy ships destroyed 10 COMMERCE Profit on arms 151,330 Profit on ship's equipment 21,854 CONDUCTS Honored permadeath Never destroyed friendly ships or stations DAMAGE SUSTAINED light plasteel armor 1,115 class II deflector 3,430 ENEMY SHIPS DESTROYED Iocrym command ship 1 Huygens Explorer 1 Iocrym sentinel 1 Aquila-class cruiser 4 Meth enforcer 1 Wind slaver 2 EXPLORATION Systems visited 25 Never reached the Galactic Core EXTENSIONS The Stars of the Pilgrim HD FINAL EQUIPMENT dual laser cannon NAMI missile launcher class II deflector 4 damaged segments of light plasteel armor Nova-10 reactor ITEMS INSTALLED light plasteel armor NAMI missile launcher class II deflector dual laser cannon Nova-10 reactor MISSIONS & ACTIVITIES Slaves offered to Domina 21