Unmodded game of course --- it would be very easy to breeze through the game with tons of helping mods.
1. Pre-S.K. space
-How do you make the initial jump from being cashless and fighting through Eridani? Probably more useful if you include which ship you are using since it makes a huge difference.
-Related to the above: Where do you get the first bits of cash to afford fuel and what do you do with the cash?
-About how much cash do you obtain before moving on?
-Is mining worth it anymore? I remember you used to be able to get Duralloy in the second system before (allowed you to craft level 6 armor with a tinker), but now it seems to be mostly level 1 and 2 ores --- really cheap and maybe even not worth the fuel?
-What do you do with the items you want to keep, but can't hold?
-Probably related....How do you kill the Salvager nomads in the early game?
-I generally prefer to use a monopole deflector until better comes along. What would you say your preference for an early game shield is and for how long do you keep it before upgrading? (please don't say Class V

-When do you feel capable of taking on level 2 Korolov missons with the pirate ships? If the answer is when you have an omni turbolaser, what if you don't find one?
-Do you search systems for the random wrecks? Is it worthwhile or a gamble on fuel?
-Do you do the arena?
-If you do, what kind of armor, weapons, devices, and shields do you prefer for it and how soon do you do it?
-MAG launchers.....that is all =/
-How do you deal with Charon. I don't think I've ever managed to actually save it post .99c without godmoding my ship.
-How do you kill the fortress with its dual omni particle beams?
Post S.K. (Sung Space)
-What upgrades do you prefer to have before moving on?
-Where do you get the money for these upgrades?
-How do you deal with Sung Slave Camps/Fortresses/ in general?
-Do you feel a howitzer is necessary? Particle resistant/reflecting barrels/gems necessary?
-Do you skip Dwarg camps (3-4 in a cluster) completely like I do now

-Earliest point to grind Ferians? (what weapon combo to safely take out warriors)
-Do you backtrack now to earlier systems to take out skipped camps?
-What camps are the ones you tend to skip the most?
-BTW, do Marauder outposts respawn Marauder platforms for farming 100mw reactors?
-How do you maintain fuel (mostly a problem if you have a hungry shield and a small reactor)
Sanctuary space (pre-Ares)
-I've always had trouble with this break point. How do you gear up for this? The difficulty seems to jump with Xenophobes, Ventari, and higher Sung camps
-How do you make the transition from your 100mw power level to being able to farm Ventari for their 250mw reactor?
-What is your main source of cash at this point? Do you save higher items now for the shift to rin currency or do you sell your higher military items to survive this shift?
-Your preferred loadout at this point.
-Any special tricks? I'll say that I don't have much experience with this space without mods.
Ares Space
-Even with mods, when I first get here Ares' ion cannons rip me apart if I engage a group of 4 or more sandstorms. How do you deal with the change in damage source?
-How do you manage to get rin to get the higher items from Taikon and the Ringers?
-Where do you normally get the 500mw reactor and the 1gw reactor now that you can't order the Hyperion anymore?
-What loadout do you have now before you get to the end game loadouts (I would say probably the level 7 or 8 weapons/shields here)
-How do you maintain fuel at this point? Basically, I find that a level 7+ shield is needed at this point, but I find that I'm probably still stuck with a 250mw reactor. Your shield draining 100mw+ along with your weapons/devices really hurts me before I upgrade my reactor ---but anything less than a level 7 shield gets eaten far too quickly.
Heretic
-There are several tips around, but what order do you generally take in Heretic?
-What weapons do you use vs the sentinels (since that is the bigger problem than the big boss himself)
Anyway, you don't have to answer all the questions. It is probably a long list. I can post some of what I do and what loadouts I prefer, but I rather ask first so I don't influence the answers of others. Maybe this can give me more insight about how others deal with these situations that I have trouble with.