Normally I perhaps don't bother with this sort of thing but honestly come on:
Neil Patrick Harris + Joss Whedon + Nathan Fillon + supervillains + musical format = AWESOME^2, yes that is awesome SQUARED my friends.
http://www.drhorrible.com/
Not to mention it's groundbreaking format (a professionally made, albeit low budget, direct to the internet mini-movie kind of thing? Sign me up) by it's very nature it is full of win in every way possible.
Watch quickly cause they are taking it down tomorrow.
